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Schematic diagram showing the HHcy-mediated effects at different stages of atherogenesis. HHcy-induced oxidative stress enhancement is the key player behind all of these influences. The adverse effects of HHcy on OxLDL and PON1 also indirectly contribute to HHcy-induced atherogenesis. Both exercise and H2S are presumed to antagonize HHcy-induced oxidative stress enhancement, thereby preventing atherogenesis.
