Methionine cycle and transsulfuration pathway. THF, tetrahydrofolate; CH2-THF, methylene-tetrahydrofolate; CH3-THF, methyl-tetrahydrofolate; MS, methionine synthase; BHMT, betaine-dependent homocysteine methyltransferase; CBS, cystathionine β synthase; CGL, cystathionine γ lyase