Table 2.

Seed regions with increased functional connectivity in ME/CFS vs. HC

Seed Region	Cluster Coordinates	Cluster Size	Cluster Regions	Voxels in Region	% Coverage	Cluster p-value (<.05 FDR)	HC Connectivity Mean (SD)	CFS Connectivity Mean (SD)
Right Superior Frontal Gyrus	−08, −72, 52	328	Precuneus	178	3	.0008	−.13 (.16)	.19 (.20)
			Right Postcentral Gyrus	36	1
			Not assigned or less than 1% coverage	114	-
Left Superior Frontal Gyrus	04, −66, 60	195	Precuneus	156	3	.04	−.08 (.19)	.21 (.15)
			Not assigned or less than 1% coverage	39	-
	02, −42, 74	172	Precuneus	41	1	.04	−.22 (.20)	.16 (.28)
			Left Postcentral Gyrus	23	1
			Right Postcentral Gyrus	19	1
			Not assigned or less than 1% coverage	89	-
Anterior Cingulate Cortex	−08, −40, 10	259	Posterior Cingulate Gyrus	23	1	.01	−.34 (.17)	.15 (.26)
			Left Thalamus	22	2
			Left Hippocampus	7	1
			Not assigned or less than 1% coverage	207	-
Precuneus	−06, −06, 66	465	Left Supplementary Motor Area	153	24	.0004	.01 (.17)	.29 (.12)
			Right Supplementary Motor Area	85	12
			Left Superior Frontal Gyrus	49	2
			Right Precentral Gyrus	29	1
			Right Superior Frontal Gyrus	14	1
			Not assigned or less than 1% coverage	125	-
Right Angular Gyrus	28, −26, 78	361	Right Precentral Gyrus	117	3	.004	−.07 (.18)	.25 (.20)
			Right Postcentral Gyrus	69	2
			Not assigned or less than 1% coverage	175	-