Table 3.

Seed regions with reduced functional connectivity in ME/CFS vs. HC

Seed Region	Cluster Coordinates	Cluster Size	Cluster Regions	Voxels in Region	% Coverage	Cluster p-Value (p <.05 FDR)	HC Connectivity Mean (SD)	CFS Connectivity Mean (SD)
Anterior Cingulate Cortex	38, −8, −4	723	Right Insula	303	23	<.0001	.38 (.11)	.09 (.14)
			Right Planum Polare	106	28
			Right Temporal Pole	79	3
			Right Putamen	58	7
			Right Heschl’s Gyrus	19	7
			Not assigned or less than 1% coverage	158	-
Left Parahippocam pal Gyrus	54, 6, 44	1163	Right Precentral Gyrus	373	9	<.00001	.21 (.11)	−.01 (.10)
			Right Middle Frontal Gyrus	365	13
			Right Inferior Frontal Gyrus (pars opercularis)	85	12
			Right Inferior Frontal Gyrus (pars triangularis)	16	3
			Not assigned or less than 1% coverage	324	-
	−54, −30, 52	251	Left Postcentral Gyrus	154	4	.002	.18 (.11)	−.02 (.11)
			Left Supramarginal Gyrus	73	8
			Not assigned or less than 1% coverage	24	0
Left Pallidum	38, −36, −10	448	Right Hippocampus	82	12	.0006	.17 (.15)	−.13 (.17)
			Right Lingual Gyrus	41	2
			Right Fusiform Cortex	34	5
			Right Parahippocam pal Gyrus	11	3
			Not assigned or less than 1% coverage	280	-
Right Pallidum	0, −62, 6	286	Left Lingual Gyrus	104	7	.03	.15 (.15)	−.09 (.12)
			Left Occipital Pole	45	2
			Left Intracalcarine Cortex	41	6
			Right Lingual Gyrus	25	1
			Not assigned or less than 1% coverage	76	-