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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: J Neurosci Res. 2016 Feb 11;94(5):401–408. doi: 10.1002/jnr.23719

Figure 4.

Figure 4

Calmodulin activity is required for mGluR1/5-mediated synaptic LTD in vitro and in vivo. (A) DHPG (n=7) or W13 plus DHPG (n=5) was infused to the CA1 region of the anesthetized mice. The changes of fEPSP during the whole recording period are presented as mean +/− SEM. (B) DHPG (n=12) or W13 plus DHPG (n=14) was applied to acute hippocampal slices, and changes of fEPSP were recorded and presented as mean +/− SEM. Representative fEPSP traces at time points 1 and 2 (as indicated) following different drug treatment are shown.