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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: J Neurosci Methods. 2016 Feb 15;263:115–122. doi: 10.1016/j.jneumeth.2016.02.013

Figure 8. Time course for recovery of CFA-induced depression of wheel running.

Figure 8

Top: CFA was injected into the right hindpaw of male and female rats after 8 days of exposure to the wheel in the rat’s home cage. Unilateral inflammation of the hindpaw almost completely inhibited wheel running in male (n = 4) and female (n = 6) rats. Wheel running gradually returned to baseline levels following induction of inflammation. Bottom: Unilateral hindpaw inflammation decreased mechanical withdrawal thresholds in male and female rats. Unlike wheel running, there was no recovery in mechanical withdrawal thresholds within 14 days. * indicates that groups differ as determined by 95% confidence intervals.