Figure 3.

Cross-talk between apoptosis and autophagy. Common proteins in the autophagy and apoptotic pathways are shared and intimately linked in cross-talk between apoptosis and autophagy regulating cell death in mammalian cells. Degradation of key autophagy proteins such as Atg5, Atg3, Atg4D, Beclin-1 and Atg12 by active caspases represents one mechanism that limits continuous autophagosome formation. Antiapoptic Bcl-2 family members bind to Beclin-1 and restrict availability Beclin-1 for autophagosome formation and suppress autophagy. Autophagy substrate P62 participates in recruitment of caspase-8 that facilitates self-oligomerization of caspase-8 and subsequent activation. Caspase-8 once recruited to the autophagosome can also be degraded that suppresses apoptosis.