Table 6.
Relative effect sizes for risk of nausea
| Regimen | Risk of nausea | |||
|---|---|---|---|---|
| Random effects model | Fixed effect model | |||
| All vs. placebo | Exenatide QW vs. all | All vs. placebo | Exenatide QW vs. all | |
| Odds ratio (95% CrI) | Odds ratio (95% CrI) | Odds ratio (95% CrI) | Odds ratio (95% CrI) | |
| Placebo | N/A | 4.37 (0.06, 361.04) | N/A | 3.77 (1.35, 10.69)* |
| Exenatide 5 µg BID | 2.53 (0.18, 36.05) | 1.73 (0.01, 246.66) | 2.82 (1.62, 4.96)* | 1.33 (0.43, 4.11) |
| Lixisenatide 20 µg QD | 4.45 (0.78, 27.49) | 0.98 (0.02, 52.67) | 3.86 (2.69, 5.61)* | 0.98 (0.37, 2.61) |
| Exenatide 10 µg BID | 4.69 (0.54, 40.69) | 0.93 (0.01, 86.57) | 5.22 (3.48, 7.92)* | 0.72 (0.26, 2.01) |
| Liraglutide 1.2 mg QD | 9.89 (0.21, 490.78) | 0.44 (0.01, 13.72) | 8.50 (3.19, 22.22)* | 0.44 (0.20, 1.00) |
| Liraglutide 1.8 mg QD | 12.96 (0.18, 975.55) | 0.34 (0.01, 15.75) | 11.60 (4.17, 31.79)* | 0.32 (0.14, 0.77)* |
| Dulaglutide 1.5 mg QW | 15.13 (0.09, 2563.17) | 0.29 (0.00, 33.99) | 13.56 (4.52, 40.37)* | 0.28 (0.11, 0.73)* |
| Exenatide 2 mg QW | 4.37 (0.06, 361.04) | N/A | 3.77 (1.35, 10.69)* | N/A |
BID twice daily, CrI credible interval, N/A not applicable, QD once daily, QW once weekly
* Statistically significant difference