Table 1.
Demographics and Baseline Characteristics
| eGFRcr 30 to <60 mL/min/1.73 m2 | eGFRcr ≥60 mL/min/1.73 m2 | |||||||
|---|---|---|---|---|---|---|---|---|
| Placebo | DAPA, mg/day | Placebo | DAPA, mg/day | |||||
| 5 | 10 | All DAPA | 5 | 10 | All DAPA | |||
| n | 256 | 84 | 249 | 333 | 1767 | 542 | 1847 | 2389 |
| Age, years | 65 (7.0) | 64 (7.8) | 64 (7.4) | 64 (7.5) | 59 (9.7) | 56 (9.7) | 58 (10.0) | 58 (9.9) |
| Women, n (%) | 119 (46.5) | 52 (61.9) | 115 (46.2) | 167 (50.2) | 723 (40.9) | 273 (50.4) | 760 (41.1) | 1033 (43.2) |
| Race, n (%) | ||||||||
| White | 239 (93.4) | 80 (95.2) | 227 (91.2) | 307 (92.2) | 1518 (85.9) | 463 (85.4) | 1585 (85.8) | 2048 (85.7) |
| Black | 6 (2.3) | 0 | 8 (3.2) | 8 (2.4) | 57 (3.2) | 12 (2.2) | 61 (3.3) | 73 (3.1) |
| Asian | 7 (2.7) | 3 (3.6) | 6 (2.4) | 9 (2.7) | 120 (6.8) | 52 (9.6) | 128 (6.9) | 180 (7.5) |
| Other | 4 (1.6) | 1 (1.2) | 8 (3.2) | 9 (2.7) | 72 (4.1) | 15 (2.8) | 73 (4.0) | 88 (3.7) |
| Duration of diabetes, years | 13 (8.8) | 11 (9.2) | 13 (8.5) | 12 (8.7) | 9 (7.8) | 7 (7.0) | 9 (8.0) | 9 (7.8) |
| Body weight, kg | 94.6 (18.1) | 89.4 (14.5) | 95.5 (18.5) | 94.0 (17.7) | 90.3 (18.9) | 87.3 (18.9) | 90.8 (19.4) | 90.0 (19.3) |
| BMI, kg/m2 | 33.7 (6.0) | 32.5 (5.1) | 33.9 (5.7) | 33.6 (5.6) | 32.1 (5.7) | 31.7 (5.3) | 32.2 (5.6) | 32.1 (5.5) |
| SBP, mm Hg | 131 (15.2) | 135 (15.4) | 134 (15.1) | 134 (15.2) | 132 (14.8) | 131 (16.2) | 132 (15.3) | 132 (15.5) |
| DBP, mm Hg | 76 (9.8) | 80 (8.6) | 77 (8.9) | 77 (8.9) | 79 (8.8) | 80 (8.9) | 79 (9.1) | 79 (9.0) |
| HbA1c, % [mmol/mol] |
8.01 (0.81) [64 (8.9)] |
8.18 (0.98) [66 (10.7)] |
8.16 (0.88) [66 (9.6)] |
8.16 (0.91) [66 (9.9)] |
8.19 (0.96) [66 (10.5)] |
8.25 (0.93) [67 (10.2)] |
8.17 (0.96) [66 (10.5)] |
8.19 (0.95) [66 (10.4)] |
| FPG, mmol/L | 8.9 (2.6) | 9.7 (3.1) | 9.2 (3.1) | 9.3 (3.1) | 9.3 (2.5) | 9.7 (2.8) | 9.2 (2.5) | 9.3 (2.6) |
| C-Peptide, ng/mL | 4.1 (1.9) | 4.1 (1.9) | 3.7 (1.9) | 3.9 (1.9) | 3.2 (1.6) | 3.2 (1.6) | 3.3 (1.7) | 3.3 (1.6) |
Values are mean (SD) unless otherwise indicated
BMI body mass index, DAPA dapagliflozin, DBP diastolic blood pressure, eGFRcr creatinine-based estimated glomerular filtration rate, FPG fasting plasma glucose, SBP systolic blood pressure