Table 2.
Effects of active components of Radix Scrophulariae (ACRS) on interstitial collagen volume fraction (ICVF), perivascular collagen area to luminal area ratio (PVCA), collagen types I and III volume fraction of the left ventricle in spontaneously hypertensive rats (SHR) and Wistar–Kyoto rats (WKY) ( ± SE, n = 6)
| Group | ICVF (%) | PVCA (ratio) | Collage I (%) | Collage III (%) | I/III |
|---|---|---|---|---|---|
| WKY control | 6.53 ± 4.10 | 0.78 ± 0.33 | 0.22 ± 0.20 | 0.06 ± 0.04 | 3.56 ± 2.24 |
| WKY+ 140 mg/kg ACRS | 4.29 ± 2.71 | 1.01 ± 0.66 | 0.26 ± 0.20 | 0.11 ± 0.07 | 2.89 ± 2.30 |
| SHR control | 22.55 ± 5.88†† | 10.36 ± 4.38†† | 7.78 ± 2.06†† | 0.49 ± 0.44† | 33.58 ± 26.93† |
| SHR+ 40 mg/kg captopril | 5.72 ± 4.08** | 0.92 ± 0.37** | 0.15 ± 0.10** | 0.11 ± 0.05 | 2.76 ± 3.90* |
| SHR+ 70 mg/kg ACRS | 7.51 ± 3.35** | 1.59 ± 0.52** | 0.42 ± 0.31** | 0.13 ± 0.04 | 3.97 ± 4.18* |
| SHR+ 140 mg/kg ACRS | 6.54 ± 2.08** | 0.76 ± 0.42** | 0.38 ± 0.31** | 0.08 ± 0.05* | 6.54 ± 7.79* |
| SHR+ 280 mg/kg ACRS | 10.23 ± 7.20** | 1.21 ± 0.75** | 0.48 ± 0.65** | 0.07 ± 0.06* | 7.38 ± 10.37* |
Compared with WKY control group: †† P < 0.01; compared with SHR control group: * P < 0.05; ** P < 0.01