Table 4.

Effects of active components of Radix Scrophulariae (ACRS) on mRNA expression of collagen types I and III, angiotensin converting enzyme (ACE) and transforming growth factor-β1 (TGF-β1) in spontaneously hypertensive rats (SHR) and Wistar–Kyoto rats (WKY) ($\overline{x}$ ± SE, n = 6)

Group	Collage I mRNA	Collage III mRNA	TGF-β1 mRNA	ACE mRNA
WKY control	1.03 ± 0.59	1.29 ± 0.86	0.62 ± 0.37	1.20 ± 0.59
WKY+ 140 mg/kg ACRS	1.47 ± 0.60	1.28 ± 0.85	0.85 ± 0.27	1.30 ± 0.42
SHR control	4.85 ± 2.60††	1.47 ± 0.68	1.58 ± 1.05†	5.51 ± 3.83†
SHR+ 40 mg/kg captopril	1.17 ± 0.28**	0.79 ± 0.34	0.77 ± 0.18*	1.35 ± 0.24*
SHR+ 70 mg/kg ACRS	1.39 ± 0.44**	1.32 ± 0.44	0.94 ± 0.22*	1.21 ± 0.23*
SHR+ 140 mg/kg ACRS	1.22 ± 0.51**	1.15 ± 0.51	0.60 ± 0.34*	1.25 ± 0.24*
SHR+ 280 mg/kg ACRS	1.22 ± 0.49**	1.08 ± 0.60	0.88 ± 0.18*	1.07 ± 0.20*

Values are expressed as the relative integrated intensity, and normalized to that of the GAPDH. Compared with WKY control group: ^†† P < 0.01; compared with SHR control group: * P < 0.05; ** P < 0.01