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. 2016 Mar 22;4:19. doi: 10.3389/fcell.2016.00019

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Copyright © 2016 Woods, Berbusse and Naylor.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of mitochondria distribution in AX4 and cluA⁻ cytoskeleton disrupted cells. (A) AX4 mitochondrial morphology remained dispersed and was unaffected by all treatments. The cluA⁻ clustered mitochondria phenotype was significantly decreased with more loose clusters and dispersed mitochondrial when treated with latrunculin-B (p < 0.0001) or nocodazole (p < 0.0001). (B,C) Examples of mitochondrial distribution. (B) AX4 cell with dispersed mitochondria, (C) cluA⁻ cells where top cell (with arrow) shows loosely clustered mitochondria, bottom cell (with arrowhead) shows a tight cluster. ^*Indicates significant differences.