Table 2.

Dose-escalation of irinotecan

Dose (mg/m2)	No. of patients
350	6
400	3
450	3
500	6
550	2*
500	12†

^*These two patients developed grade 3 toxicity; thereafter, 12 additional patients were enrolled into the expansion portion of the study to further assess irinotecan toxicity.

^†Expansion cohort.