. Author manuscript; available in PMC: 2016 Mar 22.

Published in final edited form as: J Diabetes Complications. 2014 Apr 16;28(5):742–749. doi: 10.1016/j.jdiacomp.2014.04.003

Table 4.

Analysis of HbA_1c-adjusted number needed to harm with NPH vs Glargine.

	NPH–Glargine 486/498
	NNH	(95% CI)	p value^a
Total hypoglycemia (all symptomatic)^b	22	[−∞, − 293)∪(11,+∞]^c	0.0682
Symptomatic b2.0 mmol/L (<36 mg/dL)	16	(9, 279)	0.0377
Symptomatic b3.9 mmol/L (<70 mg/dL)	19	(10, 1213)	0.0466
Severe^d	25	(13, 326)	0.0340
All daytime	16	(9, 152)	0.0291
All nocturnal	28	[−∞, −37)∪(11,+∞]^c	0.2583

Increased hypoglycemia with NPH indicated by 1 ≤ NNH b ∞; NNH = number needed to harm; CI = confidence interval; SMBG = self-monitoring of blood glucose.

Two-sided p-value for the null hypothesis NNH = ± ∞.

Irrespective of time of day and SMBG values.

∪ indicates the set union of the disjoint intervals.

Symptomatic hypoglycemia requiring assistance and having either SMBG ≤3.1 mmol/L or prompt recovery after oral carbohydrate, intravenous glucose, or glucagon administration.