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. 2016 Mar 18;7:11012. doi: 10.1038/ncomms11012

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(a) Schematic diagram showing the screening strategy used to investigate the miRNA target sites along the 3′UTR of three pairs of ligands/receptors. (b) Cutoff value was set according to 50 control experiments. (c) SAMcell assay demonstrated the consistent results in the luciferase assay. Eight randomly selected miRNAs, including miR26a, 222, 365, 99b*, 496, 369, 99a or 216, were examined to target HGF/HGFR in humans and mice. (d) Column diagram showing the number of four types of miRNA target sites in HGF/HGFR, TGFβ1/TGFβR1 or FGF/FGFR, including unique, common, cooperative and orthogonal type. Cooperative type refers to the situation in which a pair of a ligand and receptor was simultaneously targeted by one certain miRNA in one species.