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. 2016 Mar 18;7:11030. doi: 10.1038/ncomms11030

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(a) UV-visible absorption spectra of PGRMC1 (a.a.44–195). Measurements were performed in the presence of the oxidized form of haem (ferric), the reduced form of haem (ferrous) and the reduced form of haem plus CO gas (ferrous+CO). (b) Close-up view of haem stacking. Spheres are drawn with van der Waals radii. (c) Gel-filtration chromatography analyses of PGRMC1 (a.a.44–195) wild-type (wt) and the Y113F or C129S mutant in the presence or absence of haem, dithionite and/or CO. (d) Transition model for structural regulation of PGRMC1 in response to haem and CO.