FIGURE 1.

Effects of 5-HT receptor antagonists on TNBS-induced disease severity. DAI at day 4 (A), MS (B), colonic length (C), and colonic thickness (D) assessed in normal mice (N) and in TNBS-treated mice administered with vehicle (C), WAY100135 5 mg/kg (W), Ketanserin 5 mg/kg (K), Ondansetron 10mg/kg (O), GR125487 10 mg/kg (G) and SB269970 10 mg/kg (S) (n = 6–12 data per group). ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001 vs. N mice; ^#P < 0.05, ^##P < 0.01 vs. C mice; one-way ANOVA followed by Bonferroni’s post-test. Kruskal–Wallis analysis followed by Dunn’s post-test was applied for statistical comparison of DAI and MS.