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. 2016 Mar 21;7:10962. doi: 10.1038/ncomms10962

Figure 2. Selectively activating GABAergic interneurons inhibits multi-unit activity during ictal seizures.

Figure 2

(a,f) Targeting sites for optical stimulation and electrical recording in vivo. (b,d,g,i) Representative examples of multi-unit firing rates in the DGH (b,g) and MEC (d,i) at the indicated times before, during and after 60 s optical stimulation. (c,e,h,j) Averaged multi-unit firing rates in the DGH (c, n=61 from 5 mice; h, n=47 from 5 mice) and MEC (e, n=48 from 5 mice; j, n=43 from 5 mice), respectively. Light pulses (473 nm, 5 ms pulse duration at 130 Hz) were delivered into the DGH (a–e) and MEC (f–j) at time 0. The thick blue line denotes the 60-s stimulation period. Error bars represent s.e.m. Stars represent significant differences (*P<0.05, **P<0.01, ***P<0.001, paired t-test.).