Table 1. Characteristics of the replicated kit ligand (KITLG) locus from the cortisol stress reactivity epigenome-wide association study (EWAS).
| Cg number | 27512205 |
|---|---|
| Gene | KITLG |
| Location | Chr 12: 88579621 north-shore CpG island |
| Discovery mean methylation* (range) | 0.15 (0.12–0.19) |
| Replication mean methylation* (range) | 0.14 (0.11–0.18) |
| Cross-tissue mean methylation* (range) | 0.09 (0.07–0.12) |
| Discovery association cortisol AUCi | B=−1,161, P=5.8 × 10−6† |
| Blood replication association cortisol AUCi | B=−1,040, P=0.006† |
| Cross-tissue association cortisol AUCi | B=−104, P=0.003† |
| Discovery association CTQ | B=0.005, P=0.04† |
| Blood replication association CTQ | B=0.001, P=0.146 |
AUCi, area under the curve (AUC) with respect to the increase; CTQ, Childhood Trauma Questionnaire.
*Methylation in percentage (beta).
†Denotes a nominal association in a linear regression model (P<0.05).