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. 2016 Mar 22;6:23531. doi: 10.1038/srep23531

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Copyright © 2016, Macmillan Publishers Limited

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The blue Boxplot represent LOH group, green Boxplot represent healthy control group. Expression levels of the miRNAs (LnΔCq scale at Y-axis) were normalized by the mean Cq value of let-7b-5p, let-7i-3p and U6 snRNA. Low expression level of the miRNA has a high LnΔCq scale. The line represents the median value. Wilcoxon signed-rank test was used to determine statistical significance. (a) Investigation of 16 selected single miRNAs using fq-RT-PCR in training set. The results showed that miR-125a-5p, miR-361-5p, miR-150-5p and miR-133a-3p were significantly decreased in LOH patients when compared with control group; while miR-1301-3p was increased in LOH patients. (b) Large-scale validation of the 5 miRNAs that were selected from the training set. The results showed that miR-125a-5p, miR-361-5p and miR-133a-3p were significantly decreased in LOH patients compared with healthy controls.