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. 2016 Mar 22;6:23440. doi: 10.1038/srep23440

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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2-dimensional colourmap display of the scale of effects scored in terms of the numbers of reactions affected (reaction pairs) with respect to the total number of possible pairs in affected pathways on knockdown of reactions of a given pathway (in percentages) (A) positively correlated reactions, (B) negatively correlated reactions. The colour code corresponding to the numbers of affected reactions is shown in the corresponding scale bar. The knockdown pathways are in the rows and the affected pathways are in the columns.