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. 2016 Mar 22;6:23432. doi: 10.1038/srep23432

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Copyright © 2016, Macmillan Publishers Limited

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(A) Structure of the 4 phenylamino-substituted naphthalenes synthesized and analyzed in the present study. (B) Antiproliferative activity of the four anilino-naphthalenes was analyzed as in Fig. 4A. Data are the percentage of control proliferation (in absence of molecules). (C) Graphical representation of the combined ¹HN and ¹⁵N FGF2 chemical shift perturbation determined for the various residues, according to³⁶ , following the addition of phenylamino-substituted naphthalenes. C) Chemical shift perturbation (CSP) induced by SM.1–34 addition in SM:FGF2 1:1 stoichiometric ratio D) CSP induced by SM.1–31 addition in SM:FGF2 1:3 stoichiometric ratio. The continuous and dashed lines represent the average and the average plus a standard deviation (SD) values, respectively. Residues affected by CSP > (<CSP>) + 1SD are mapped on the FGF2 structures as orange spheres. Residues Arg129 and Lys144, showing the highest CSP, are shown as red spheres.

Inline graphic — (A) Structure of the 4 phenylamino-substituted naphthalenes synthesized and analyzed in the present study. (B) Antiproliferative activity of the four anilino-naphthalenes was analyzed as in Fig. 4A. Data are the percentage of control proliferation (in absence of molecules). (C) Graphical representation of the combined ¹HN and ¹⁵N FGF2 chemical shift perturbation determined for the various residues, according to³⁶ , following the addition of phenylamino-substituted naphthalenes. C) Chemical shift perturbation (CSP) induced by SM.1–34 addition in SM:FGF2 1:1 stoichiometric ratio D) CSP induced by SM.1–31 addition in SM:FGF2 1:3 stoichiometric ratio. The continuous and dashed lines represent the average and the average plus a standard deviation (SD) values, respectively. Residues affected by CSP > (<CSP>) + 1SD are mapped on the FGF2 structures as orange spheres. Residues Arg129 and Lys144, showing the highest CSP, are shown as red spheres.