Table 3. Stratified analysis of the SNP rs2294008 genotypes associated with cervical cancer risk by selected variables.
| Variables | Genotypes (cases/controls) | P | Adjusted OR (95% CI)a | |
|---|---|---|---|---|
| CC/CT | TT | |||
| Set | ||||
| Test | 545/604 | 26/53 | 0.012 | 0.54 (0.33–0.89) |
| Validation | 533/541 | 22/39 | 0.039 | 0.56 (0.34–0.98) |
| Age (years) | ||||
| ≤ 49 | 584/638 | 27/44 | 0.109 | 0.72 (0.44–1.19) |
| >49 | 494/507 | 21/48 | 0.002 | 0.42 (0.25–0.72) |
| Parity | ||||
| 0–1 | 592/834 | 29/67 | 0.029 | 0.63 (0.40–0.99) |
| ≥2 | 461/228 | 18/16 | 0.093 | 0.57 (0.28–1.14) |
| Abortion | ||||
| No | 350/345 | 23/26 | 0.643 | 0.82 (0.46–1.49) |
| Yes | 679/676 | 24/58 | <0.001 | 0.42 (0.26–0.69) |
| Menopausal status | ||||
| Premenopausal | 570/657 | 27/52 | 0.034 | 0.60 (0.37–0.97) |
| Postmenopausal | 479/404 | 21/37 | 0.008 | 0.50 (0.29–0.87) |
| Depth of invasion | ||||
| I | 710/1145 | 30/92 | 0.53 (0.34–0.81) | |
| II | 317/1145 | 17/92 | 0.67 (0.39–1.15) | |
| III/IV | 37/1145 | 1/92 | 0.33 (0.05–2.46) | |
aAdjusted for age, parity, and menopausal status in logistic regression model.