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. 2016 Mar 22;6:23344. doi: 10.1038/srep23344

Figure 3. Proton potentiation is independent of residues in the NTD and CTD layers.

Figure 3

Glycine-elicited whole-cell currents (0.5 mM, −70 mV) recorded at the indicated pH values from HEK293 cells expressing: (a) GluN1-1b/GluN3A receptors or (b) receptors lacking the entire NTD layer (ΔNTD). (c) pH-dependence of Ipk relative to pH 6.8 for receptors with the indicated GluN1 CTD sequences (▿, GluN1-2a (2a); ○, GluN1-3a (3a); □ GluN1-4a (4a); Δ, GluN1838stop (ΔCTD)). Values are means ± SEM; sample size is in bars; *P < 0.05 relative to pH 7.4.