Table 2.
Univariate (p value) and multivariate analysis (p value adj) of the candidate single nucleotide polymorphisms for the development of new-onset diabetes after transplantation.
| SNP | Gene | Location | Minor allele | MAF | p value | p value adj | Odds ratio (95% CI) |
|---|---|---|---|---|---|---|---|
| rs16936667 | PRDM14 | 8:70975726 | G | 0.16 | 0.03 | 0.01 | 10.6 (1.8–63.0) |
| rs1801282 | PPARG | 3:12393125 | G | 0.1 | 0.12 | 0.02 | 8.5 (1.4–52.7) |
| rs8192678 | PPARGC1A | 4:23815662 | A | 0.34 | 0.17 | 0.03 | 0.26 (0.08–0.91) |
| rs2144908 | HNF4A | 20:42985717 | A | 0.18 | 0.05 | 0.04 | 7.0 (1.1–45.0) |
| rs2340721 | ATF6 | 1:161849385 | A | 0.3 | 0.006 | 0.05 | 0.21 (0.04–1.0) |
| rs5219 | KCNJ11 | 11:17409572 | T | 0.34 | 0.08 | 0.12 | 2.7 (0.77–9.8) |
| rs10899444 | SHANK2 | 11:70606500 | G | 0.15 | 0.77 | 0.15 | 0.32 (0.07–1.5) |
| rs1025689 | IL-17RB | 3:53883722 | G | 0.44 | 0.14 | 0.15 | 0.45 (0.15–1.34) |
| rs1124053 | IL-17E | 14:22914819 | T | 0.23 | 0.05 | 0.16 | 2.7 (0.68–10.3) |
| rs2265477 | SHPRH | 6:146212338 | C | 0.46 | 0.54 | 0.17 | 0.45 (0.14–1.4) |
| rs6793265 | ITPR1 | 3:4735533 | T | 0.13 | 0.22 | 0.23 | 2.2 (0.60–8.4) |
| rs7145618 | PPP2R5C | 14:102329098 | C | 0.07 | 0.64 | 0.25 | 3.1 (0.44–21.5) |
| rs1783606 | SHANK2 | 11:70576651 | A | 0.14 | 0.99 | 0.26 | 0.42 (0.09–1.9) |
| rs2265919 | SHPRH | 6:146221753 | G | 0.44 | 0.74 | 0.29 | 0.54 (0.18–1.7) |
| rs3212574 | ITGA2 | 5:52366779 | A | 0.23 | 0.94 | 0.30 | 2.1 (0.50–9.2) |
| rs2107538 | CCL5 | 17:34207780 | T | 0.18 | 0.07 | 0.34 | 2.1 (0.46–9.5) |
| rs2240747 | ZNRF4 | 19:5456930 | C | 0.21 | 0.86 | 0.37 | 2.0 (0.45–8.7) |
| rs17657199 | NDST1 | 5:149950246 | T | 0.03 | 0.37 | 0.41 | 2.5 (0.28–23.3) |
| rs3817655 | CCL5 | 17:34199641 | A | 0.18 | 0.12 | 0.48 | 1.8 (0.37–8.5) |
| rs4819554 | IL-17RA | 22:17565035 | G | 0.12 | 0.62 | 0.49 | 1.7 (0.38–7.9) |
| rs341497 | DIAPH3 | 13:60429001 | C | 0.06 | 0.45 | 0.49 | 2.0 (0.28–14.1) |
| rs1800795 | IL-6 | 7:22766645 | C | 0.43 | 0.90 | 0.53 | 0.72 (0.26–2.0) |
| rs2280789 | CCL5 | 17:34207003 | C | 0.13 | 0.14 | 0.59 | 1.7 (0.26–10.7) |
| rs1799854 | ABCC8 | 11:17448704 | T | 0.4 | 0.51 | 0.60 | 0.75 (0.25–2.2) |
| rs1016429 | GRIN3A | 9:104402364 | C | 0.1 | 0.41 | 0.64 | 1.6 (0.24–10.0) |
| rs2069762 | IL-2 | 4:123377980 | G | 0.25 | 0.21 | 0.66 | 1.3 (0.39–4.4) |
| rs1494558 | IL-7R | 5:35861068 | A | 0.35 | 0.79 | 0.70 | 1.2 (0.46–3.2) |
| rs2172749 | IL-7R | 5:35855264 | C | 0.35 | 0.79 | 0.70 | 1.2 (0.46–3.2) |
| rs1043261 | IL-17RB | 3:53899276 | T | 0.11 | 0.23 | 0.71 | 0.73 (0.14–3.8) |
| rs1044498 | ENPP1 | 6:132172368 | C | 0.14 | 0.21 | 0.74 | 0.80 (0.21–3.1) |
| rs2070874 | IL-4 | 5:132009710 | T | 0.17 | 0.60 | 0.78 | 0.82 (0.21–3.3) |
| rs10117679 | GRIN3A | 9:104378479 | T | 0.06 | 0.44 | 0.81 | 1.4 (0.1–18.3) |
| rs1169288 | HNF1A | 12:121416650 | G | 0.36 | 0.96 | 0.82 | 1.1 (0.35–3.8) |
| rs13266634 | SLC30A8 | 8:118184783 | T | 0.38 | 0.53 | 0.84 | 0.89 (0.30–2.7) |
| rs12255372 | TCF7L2 | 10:114808902 | T | 0.28 | 0.94 | 0.91 | 1.1 (0.41–2.7) |
| rs1871184 | ITGA1 | 5:52234323 | T | 0.13 | 0.14 | 0.92 | 1.1 (0.16–7.4) |
| rs17722392 | KIDINS220 | 2:8940154 | C | 0.05 | 0.44 | 0.93 | 1.1 (0.09–13.8) |
Key: SNP: single nucleotide polymorphism, MAF: minor allele frequency, p value adj: p value adjusted for age, sex, body mass index at baseline and change after 12 months, CI: confidence interval.
Bold values indicate significance at p value ≤ 0.05.