Table 2.
LPL and HL activities and lipid parameters on morbidly obese liver patients in each group before and after bariatric surgery.
| LIVER |
Anova-2, p value |
||||||
|---|---|---|---|---|---|---|---|
| Parameters | Control (n = 7) | Time | DM − DL − (n = 9) | DM − DL + (n = 14) | DM + DL + (n = 6) | Comorbidities effect | Surgery effect |
| LPL (mU/g tissue) | 36.8 ± 2.1 | OB | 78.7 ± 10.8c | 97.4 ± 8.6cc | 72.7 ± 17.6 | ns | ns |
| 12 M | 68.7 ± 17.3 | 67.7 ± 19.9 | 67.0 ± 10.3 | ||||
| p = ns | p = 0.0295 | p = ns | |||||
| HL (mU/g tissue) | 153.2 ± 9.3 | OB | 303.7 ± 26.3cc | 253.2 ± 20.1c | 231.5 ± 31.3c | ns | < 0.0001 |
| 12 M | 146.8 ± 16.7oo | 142.6 ± 30.4o | 115.5 ± 6.2o | ||||
| p = 0.0036 | p = 0.0081 | p = 0.0430 | |||||
| Lipid (mg/g tissue) | 24.0 ± 2.0 | OB | 201.1 ± 25.2ccc | 178.1 ± 40.0ccc | 244.4 ± 38.7c | 0.0087 | 0.0001 |
| 12 M | 27.5 ± 4.6ooo | 74.0 ± 27.2o,c | 69.9 ± 1.4o,c | ||||
| p < 0.0001 | p = ns | p = 0.0065 | |||||
| Lipid (mg/mg DNA) | 10.8 ± 2.0 | OB | 105.9 ± 18.7cc | 102.7 ± 24.4c | 148.0 ± 23.2ccc | 0.0049 | 0.0017 |
| 12 M | 19.7 ± 5.0oo | 49.3 ± 16.9o | 55.8 ± 9.7o,c | ||||
| p = 0.0009 | p = ns | p = 0.0007 | |||||
| TAG (mg/mg DNA) | 6.4 ± 1.6 | OB | 44.0 ± 8.6cc | 40.0 ± 10.4 | 57.6 ± 9.8ccc | 0.0219 | 0.0532 (ns) |
| 12 M | 9.6 ± 1.2oo | 26.9 ± 10.2 | 34.7 ± 14.9 | ||||
| p = 0.0040 | p = ns | p = 0.0226 | |||||
| TC (mg/mg DNA) | 0.44 ± 0.08 | OB | 12.5 ± 2.3c | 13.3 ± 3.2c | 19.0 ± 2.5cc | 0.0095 | < 0.0001 |
| 12 M | 2.2 ± 0.5o,c | 3.5 ± 1.9o | 2.4 ± 1.2oo | ||||
| p = 0.0070 | p = ns | p = 0.0008 | |||||
| NEFA (mg/mg DNA) | 0.23 ± 0.08 | OB | 6.8 ± 1.4cc | 8.5 ± 1.0ccc | 8.5 ± 1.2ccc | < 0.0001 | ns |
| 12 M | 4.7 ± 1.1c | 10.9 ± 0.3c | 6.4 ± 0.9c | ||||
| p = 0.0508 | p = ns | p = 0.0021 | |||||
| PL (mg/mg DNA) | 2.43 ± 0.45 | OB | 42.59 ± 8.97cc | 48.04 ± 12.25cc | 79.35 ± 8.92ccc | 0.0026 | < 0.0001 |
| 12 M | 5.70 ± 1.52o | 8.32 ± 2.63oo | 9.05 ± 0.87ooo | ||||
| p = 0.0143 | p = 0.0475 | p = ns | |||||
| CRP (mg/mg DNA) | 0.09 ± 0.05 | OB | 2.78 ± 0.51cc | 6.02 ± 1.32c | 3.44 ± 1.14 | 0.0396 | 0.0003 |
| 12 M | 0.0 ± 0.0ooo | 0.41 ± 0.19o | 0.21 ± 0.21 | ||||
| p = 0.0003 | p = 0.0108 | p = 0.0419 | |||||
The data are expressed as the means ± SEM. Abbreviations: LPL, lipoprotein lipase; HL, hepatic lipase; mU, nmol/min; PL, phospholipid. The (o) symbol indicates the differences between obese and 6 or 12 months after surgery in each group; the (c) symbol indicates the differences between each time and obese group vs. control (lean) group. One symbol, p < 0.05; two symbols, p < 0.01; three symbols, p < 0.001; ns, non-significant.