Fig. 3.

Searches for MTB/GF genes of interest (GOI) in the REMBRANDT database. Genes were chosen based on functional relevance and REMBRANDT [8] expression data. Section 3.2 explains the selection of GOI indicated with red arrows in detail. (a) Functional groupings. (b) Utilization of expression levels above two-fold in selection of GOI in the carbonic anhydrase and solute carrier 16 families of genes. Expression levels that had significant p-values (< 0.05) for poorer survival (Kaplan Meier) are bolded. The full gene names are as follows: ACLY (ATP citrate lyase), ACTB (actin B), ALDOA (aldolase A), CA (carbonic anhydrase), EGF (epidermal growth factor), ENO1 (enolase 1), FBP1 (fructose 1,6 bisphosphatase), FOXC2 (forkhead box C2), GAPDH (glyceraldehyde-3-phosphate dehydrogenase), GBE1 (glycogen binding enzyme), GCK (glucokinase), GPI (glucophosphoisomerase), GYS1 (glycogen synthase 1), HBEGF (heparin-binding EGF like growth factor), HGF (hepatocyte growth factor), HIF1A (hypoxia-inducible factor 1, alpha subunit), HK (hexokinase), IGF2 (insulin-like growth factor II), LDH (lactate dehydrogenase), ME1 (malic enzyme 1), PCK (phosphoenolpyruvate carboxykinase), PDGF (platelet-derived growth factor), PDHX (pyruvate dehydrogenase complex, component X), PFKFB4 (6-phosphofructo-2-kinase/fructose-2,6 bisphosphatase 4), PGAM2 (phosphoglycerate mutase 2), PGK1 (phosphoglycerate kinase 1), PFKL (phosphofructokinase L), PKM2 (pyruvate kinase, muscle, 2), PYGL (glycogen phosphorylase, liver), SDH (succinate dehydrogenase complex), SLC2 (solute carrier family 2), SLC16 (solute carrier family 16), TGFB (transforming growth factor, beta), and TPI1 (triosephosphate isomerase 1). Note that SCL16A3 is also known as MCT4 (monocarboxylate transporter 4).