Table 2.
1. ACLY, ATP citrate lyase | Cleaves citric acid, synthesizes acetyl CoA |
2. CA3, Carbonic anhydrase III | Interconversions of CO2/HCO3− in cytoplasm |
3. CA12, Carbonic anhydrase XII | Interconversions of CO2/HCO3− at cell surface |
4. ENO1, Enolase 1* | Catalyzes ninth of ten steps in glycolysis |
5. GYS1, Glycogen synthase 1 | Synthesis of glycogen from simpler carbohydrates |
6. HIF1A, Hypoxia-inducible factor 1, alpha subunit | Transcription factor, upregulates genes in hypoxia |
7. LDHA, Lactate Dehydrogenase A | Interconversion of lactic acid and pyruvate |
8. LDHC, Lactate Dehydrogenase Cǂ | Interconversion of lactic acid and pyruvate |
9. SLC16A3, Solute carrier family 16 (monocarboxylic acid transporter), member 3. See protein name |
Transports lactic acid and pyruvate across membranes, protein called monocarboxylate transporter 4 (MCT4) |
10. SLC16A4, Solute carrier family 16 (monocarboxylic acid transporter), member 4. See protein name |
Transports lactic acid and pyruvate across membranes, proteincalled monocarboxylate transporter 5 (MCT5) |
11. EGF, Epidermal Growth Factor | Differentiation, etc. |
12. PDGFA,Platelet-derived growth factor, alpha polypeptide |
Mesenchymal cell mitogenesis, etc. |
13. ACTB, Actin B | Structural, Housekeeping gene (HKG) for RT-qPCR |
14. GAPDH, Glyceraldehyde-3- phosphate dehydrogenase |
Glycolysis, Housekeeping gene (HKG) for RT-qPCR |
ENO1 was used to transform the expression levels of the other MTB/GF genes.
LDHC gene expression was originally thought to be limited to testes but has been found in various types of malignancy.