Table 4.
Correlations between individual MTB/GF genes and copy numbers (CN) of oncogenes, listed horizontally, in 22 glioblastomas. Expression values of MTB/GF genes after ddCt normalization were divided by concurrent expression levels of normalized ENO1 to obtain MTB/GF values as multiples of ENO1's expression prior to calculating correlations. Positive correlations less than 0.2 are indicated by ‘+’ and the negative ones are indicated by ‘-’. Genes are listed in the order of their chromosomal loci. Similar patterns of correlations for potential amplicons comprised of oncogenes are indicated in the bottom row. Note that SLC16A3 is also known as MCT4.
| MTB/GF genes listed below | 1q32.1 |
3q26.2 |
3q26.32 |
4q12 |
7p11.2 |
7q21.2 |
8q12.1 |
8q24.13 |
8q24.21 |
11q13.3 |
12p13.32 |
12q14.1 |
15q25.1 |
20q13.32 |
Xq25 |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDM4 | PIK3C2B | EVI1 | PIK3CA | PDGFRA | EGFR | CDK6 | MOS | RNF139 | MYC | CCND1 | CTTN | FGF3 | FGF4 | CCND2 | CYP27B1 | CDK4 | BCL2A1 | GNAS | XIAP | |
| 1p13.3 SLC16A4 |
||||||||||||||||||||
| − | − | − | + | 0.28 | + | − | + | + | − | + | − | − | − | − | − | − | 0.24 | 0.22 | + | |
| 4q25 EGF |
||||||||||||||||||||
| − | − | + | − | 0.39 | 0.25 | 0.37 | − | − | − | − | − | − | − | − | − | − | − | − | + | |
| 7p22.3 PDGFA |
||||||||||||||||||||
| − | − | − | − | 0.63 | 0.40 | + | − | − | − | − | − | − | − | − | − | − | + | 0.27 | − | |
| 8q21.2 CA3 |
||||||||||||||||||||
| 0.33 | 0.34 | 0.24 | + | − | + | + | 0.46 | 0.35 | 0.46 | − | − | − | − | − | 0.41 | 0.44 | 0.36 | + | 0.00 | |
| 11p15.1 LDHA LDHC |
||||||||||||||||||||
| − | + | − | 0.28 | − | + | + | + | + | + | 0.28 | + | 0.21 | + | + | + | + | − | − | − | |
| − | + | − | 0.27 | − | + | + | 0.26 | + | + | 0.42 | 0.31 | 0.37 | 0.30 | + | + | + | − | − | − | |
| 14q23.2 HIF1A |
||||||||||||||||||||
| 0.34 | 0.46 | − | + | 0.52 | + | − | − | − | − | + | − | − | − | 0.21 | − | − | 0.34 | 0.38 | − | |
| 15q22.2 CA12 |
||||||||||||||||||||
| 0.31 | 0.33 | + | + | − | + | − | + | 0.39 | + | + | − | − | − | − | + | + | 0.19 | − | − | |
| 17q21.2 ACLY |
||||||||||||||||||||
| − | − | − | − | 0.31 | + | + | + | − | − | 0.36 | 0.33 | 0.34 | 0.30 | + | + | − | − | − | − | |
| 17q25.3 SLC16A3 |
||||||||||||||||||||
| + | 0.21 | − | − | 0.20 | + | − | 0.27 | 0.20 | 0.23 | + | − | − | − | − | + | + | + | + | − | |
| 19q13.33 GYS1 |
||||||||||||||||||||
| + | + | 0.30 | 0.33 | + | 0.21 | − | − | + | − | + | + | + | + | 0.26 | + | − | + | − | − | |
| Similar patterns for the potential amplicons | 9 of 11 MTB/GF genes | 8 of 11 MTB/GF genes | 7 of 11 MTB/GF genes | 9 of 11 MTB/GF genes | ||||||||||||||||