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. 2016 Feb 12;5(2):e002886. doi: 10.1161/JAHA.115.002886

Figure 1.

Figure 1

CSF cholesterol efflux capacity is reduced in MCI and AD. A, CSF cholesterol efflux capacity was measured in the 3 groups of participants: CH (n=47), MCI (n=35), and AD (n=26). CSF from CH participants demonstrated greater efflux capacity compared with participants with MCI or AD (*P<0.001). B, In agreement with cholesterol efflux capacity, PC levels were greater in CSF from CH participants compared with those with MCI and AD. C, The differences in CSF SM among the 3 groups were not significant. PC and SM were measured in the supernatant fraction of CSF. The 3 groups were compared using a linear regression model. The differences in cholesterol efflux among the 3 groups remained significant after adjusting for CSF PC (P=0.04). AD indicates Alzheimer's disease; CH, cognitively healthy; CSF, cerebrospinal fluid; MCI, mild cognitive impairment; PC, phosphatidylcholine; SM, sphingomyelin.