Table 6.
Clinical Outcomes at 30 Days and 2 Years in Relation to Presence of CAD and Post‐TAVI Troponin >15× ULN vs ≤15× ULN
| No CAD | Adjusted HR (95% CI) | Adjusted P Value | CAD | Adjusted HR (95% CI) | Adjusted P Value | |||
|---|---|---|---|---|---|---|---|---|
| cTnT ≤15× ULN n=99 | cTnT >15× ULN n=111 | cTnT ≤15× ULN n=140 | cTnT >15× ULN n=227 | |||||
| 30 days | ||||||||
| Death, n (%) | 2 (2.0) | 8 (7.2) | 2.42 (0.50–11.59) | 0.270 | 0 (0.0) | 20 (8.8) | ||
| Cardiovascular death, n (%) | 2 (2.0) | 6 (5.5) | 1.72 (0.34–8.76) | 0.512 | 0 (0.0) | 17 (7.5) | ||
| Cerebrovascular events | 3 (3.0) | 9 (8.1) | 2.41 (0.64–9.10) | 0.196 | 3 (2.1) | 6 (2.7) | 0.88 (0.21–3.70) | 0.857 |
| Death or major stroke, n (%) | 3 (3.0) | 12 (10.8) | 2.79 (0.77–10.09) | 0.118 | 1 (0.7) | 23 (10.1) | 12.70 (1.70–94.77) | 0.013 |
| Death, major stroke, or MI, n (%) | 2 (2.0) | 13 (11.7) | 4.59 (1.01–20.73) | 0.048 | 1 (0.7) | 24 (10.6) | 13.28 (1.78–98.87) | 0.012 |
| 2 years | ||||||||
| Death, n (%) | 11 (11.6) | 30 (29.5) | 2.59 (1.27–5.26) | 0.009 | 28 (20.8) | 74 (33.1) | 1.71 (1.10–2.65) | 0.018 |
| Cardiovascular death, n (%) | 6 (6.4) | 17 (17.5) | 2.39 (0.91–6.26) | 0.076 | 19 (14.4) | 54 (25.0) | 1.77 (1.04–3.01) | 0.035 |
| Cerebrovascular events | 5 (5.3) | 11 (10.8) | 1.89 (0.64–5.57) | 0.248 | 9 (7.0) | 13 (6.8) | 0.90 (0.38–2.14) | 0.818 |
| Death or major stroke, n (%) | 14 (14.8) | 35 (34.0) | 2.38 (1.26–4.50) | 0.008 | 30 (22.2) | 77 (34.4) | 1.67 (1.09–2.56) | 0.019 |
| Death, major stroke, or MI, n (%) | 12 (12.7) | 35 (33.9) | 2.81 (1.44–5.51) | 0.003 | 32 (23.7) | 82 (36.6) | 1.71 (1.13–2.58) | 0.011 |
Depicted are number of first events (% cumulative incidence), hazard ratios (HRs) with respective 95% CIs from Cox's regressions. Adjusted HRs were obtained after adjusting for age, renal dysfunctions and STS score. Age, renal dysfunctions and STS score had a P<0.2 univariable effect on the primary outcome all‐cause death at 30 days. Missing data were singly imputed (n=1 for renal dysfunction and n=1 for STS score). CAD indicates coronary artery disease; cTnT, cardiac troponin T; MI, myocardial infarction; STS, Society of Thoracic Surgeons; TAVI; transcatheter aortic valve implantation; ULN, upper limit of normal.