Figure 8.

Hyperglycemia reduces Kv currents. A, Whole‐cell voltage‐gated K⁺ current recorded in voltage clamp in 1 control (Ctrl) and 1 streptozotocin (STZ) myocyte. B, I‐V relation for Kv currents and I_ss for Ctrl myocytes (n=25; from 4 mice) and myocytes obtained from STZ‐treated female mice (n=27; from 10 mice at 12–30 days after onset of hyperglycemia) are shown as mean±SEM. *P<0.05 vs Ctrl. C, Whole‐cell voltage‐gated Ca²⁺ current recorded in voltage clamp at +10 mV in 1 Ctrl and 1 STZ myocyte. D, I‐V relation for I_{C aL} for Ctrl myocytes (n=21; from 3 mice) and myocytes obtained from STZ‐treated female mice (n=22; from 4 mice at 12–19 days after induction of diabetes) are shown as mean±SEM. *P<0.05 vs Ctrl. Additional properties of I_{C aL} are reported in Figure S7.