Table 2.
HRs (95% CIs) of AF for Variables Included in the Simple and Biomarker‐Enriched CHARGE‐AF Risk Models, Multi‐Ethnic Study of Atherosclerosis, 2000–2012
| Simple Model | Biomarker‐Enriched Model | |
|---|---|---|
| N | 6663 | 5477 |
| HR (95% CI) | ||
| Age, per 5 y | 1.5 (1.4, 1.6) | 1.4 (1.3, 1.5) |
| White race, vs nonwhite | 1.6 (1.3, 2.0) | 1.2 (1.0, 1.6) |
| Height, per 10 cm | 1.3 (1.1, 1.4) | 1.2 (1.0, 1.4) |
| Weight, per 15 kg | 1.2 (1.1, 1.3) | 1.3 (1.2, 1.5) |
| Systolic BP, per 20 mm Hg | 1.3 (1.1, 1.4) | 1.0 (0.9, 1.2) |
| Diastolic BP, per 10 mm Hg | 0.9 (0.8, 1.0) | 1.1 (0.9, 1.2) |
| Current smoking | 1.3 (0.9, 1.8) | 1.2 (0.8, 1.8) |
| Use of antihypertensive medication | 1.4 (1.1, 1.7) | 1.3 (1.0, 1.6) |
| Diabetes | 1.1 (0.8, 1.5) | 1.2 (0.9, 1.7) |
| Log (NT‐proBNP), per 1 unit | — | 2.0 (1.7, 2.2) |
| Log (hsCRP), per 1 unit | — | 0.9 (0.8, 1.0) |
Results from a single Cox proportional hazards model including all the covariates simultaneously. AF indicates atrial fibrillation; BP, blood pressure; CHARGE, the Cohorts for Heart and Aging Research in Genomic Epidemiology; HR, hazard ratio; hsCRP, high‐sensitivity C‐reactive protein; NT‐proBNP, N‐terminal of the prohormone B‐type natriuretic peptide.