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. 2016 Feb 18;5(2):e002815. doi: 10.1161/JAHA.115.002815

Figure 2.

Figure 2

Allogeneic MSC sheet therapy achieved donor cell survival similar to syngeneic MSC sheet therapy in the early, but not late, phase. A, Male rat MSCs, syngeneic (auto group) or allogeneic (allo group), were epicardially placed in the form of cell sheets onto female rat hearts with post‐MI heart failure. Quantitative polymerase chain reaction for the male specific SRY gene showed that donor cell survival was equivalent at days 3 and 10 between the groups but was more extensively reduced in the allo group by day 28. n=5 per group at each point, *P<0.05 vs day 3 data in each corresponding group, ✝ P<0.05 vs day 10 data in each corresponding group. B through E, Immunohistostaining showed that the majority of donor MSCs labeled with CM‐DiI were retained at the surface of the left ventricular wall similarly between groups at day 3 after epicardial placement (B and D). Thin ventricular walls represent infarct areas. By day 28, donor cell survival was more extensively reduced in the allo group compared with the auto group (C and E). Scale bar=1 mm. MSC indicates mesenchymal stromal cell; N.S., not significant; TnT, troponin T.