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. 2016 Feb 18;5(2):e002815. doi: 10.1161/JAHA.115.002815

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© 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Myocardial upregulation of immunosuppressive genes after MSC sheet placement. Quantitative reverse transcription polymerase chain reaction demonstrated that expression of immunosuppressive genes (regulating NOS2, IDO1, TGFB1, and HGF) in the whole left ventricular walls (including the MSC sheets) was not statistically different among the sham (sham treatment at 4 weeks after MI), auto (syngeneic MSC sheet placement at 4 weeks after MI), and allo (allogeneic MSC sheet placement at 4 weeks after MI) groups at day 3 (A) and day 28 (B). n=5 per group. MI indicates myocardial infarction; MSC, mesenchymal stromal cell.