Table 2.
Levels of hormones and metabolites in serum of male wild-type and Cdo1−/− mice fed basal, high-fat, or taurine-supplemented high-fat diets.
| Metabolites | Genotype–diet groups Relative abundance of metabolites |
Significance level for main effects and 2-way interactions as analyzed by a general linear model F(11,30)† |
||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Male | Female | |||||||||||||||||
| Wild type basal |
Cdo1−/− basal |
Wild type HiFat |
Cdo1−/− HiFat |
Wild type HiFat+ Tau |
Cdo1−/− HiFat+ Tau |
Wild type basal |
Cdo1−/− basal |
Wild type HiFat |
Cdo1−/− HiFat |
Wild type HiFat+ Tau |
Cdo1−/− HiFat+ Tau |
G | D | S | G*D | G*S | D*S | |
| Insulin (ng/mL) | 0.92 | 1.60 | 1.90 | 1.58 | 0.88 | 1.27 | 0.37 | 0.70 | 0.42 | 0.64 | 0.42 | 0.93 | 0.032 | < 0.0001 | 0.056 | |||
| Leptin (ng/mL) | 1.55 | 1.09 | 2.08 | 1.10 | 3.43 | 1.20 | 1.12 | 0.80 | 3.49 | 1.23 | 2.04 | 2.17 | 0.003 | 0.013 | ||||
| Resistin (ng/mL) | 19.7 | 20.4 | 20.0 | 15.8 | 20.9 | 16.1 | 18.1 | 22.9 | 22.6 | 27.5 | 18.7 | 23.1 | 0.036 | 0.022 | ||||
| Adiponectin (μg/mL) | 10.0 | 12.8 | 9.03 | 9.24 | 14.1 | 9.64 | 16.0 | 12.7 | 14.2 | 9.73 | 15.6 | 13.0 | 0.032 | |||||
| NEFA (μM) | 469 | 527 | 384 | 525 | 479 | 505 | 533 | 460 | 503 | 488 | 477 | 499 | 0.012 | |||||
| Corticosterone (ng/mL) | 108 | 126 | 108 | 62.8 | 107 | 118 | 173 | 165 | 105 | 58.7 | 163 | 168 | 0.009 | 0.039 | ||||
| Lactate (mmol/L) | 9.88 | 10.5 | 10.0 | 10.3 | 9.30 | 9.09 | 8.34 | 9.65 | 8.10 | 8.73 | 6.09 | 9.36 | 0.007 | |||||
| Triglyceride (mg/dL) | 112 | 135 | 127 | 140 | 106 | 94.5 | 68.5 | 99.0 | 60.0 | 85.5 | 67.5 | 76.5 | 0.028 | < 0.0001 | ||||
| Total Cholesterol (mg/dL) | 102 | 81.5 | 120 | 109 | 122 | 105 | 67.5 | 65.5 | 83.5 | 82.5 | 81.0 | 104 | 0.002 | < 0.0001 | 0.026 | |||
| Lipase (U/L) | 23.0 | 118 | 93.0 | 20.0 | 24.5 | 20.0 | 22.5 | 15.5 | 19.0 | 19.5 | 19.5 | 22.0 | ||||||
| Creatinine (μmol/L) | 13.2 | 12.5 | 12.2 | 14.3 | 15.0 | 10.5 | 12.0 | 13.4 | 12.0 | 11.4 | 15.0 | 12.0 | ||||||
| Urea/BUN (mg/dL) | 22.0 | 27.5 | 24.5 | 22.0 | 27.0 | 20.5 | 20.5 | 24.5 | 21.5 | 25.0 | 22.0 | 21.5 | 0.006 | 0.062 | ||||
| Glucose (mg/dL) | 545 | 541 | 530 | 601 | 564 | 623 | 593 | 478 | 440 | 591 | 636 | 580 | 0.027 | |||||
Data are the average value for two pooled samples for each group, with each pooled sample taken from three or four mice. Standard deviation values across all groups were as follows: insulin = 0.55; leptin = 0.90; resistin = 4.16; adiponectin = 3.19; NEFA = 47.79; corticosterone = 47.35; lactate = 1.45; triglyceride = 28.97; total cholesterol = 20.27; lipase = 47.23; creatinine = 2.28; urea/BUN = 2.73; Glucose=73.04. Data were analyzed for main effects and their interactions by a full-factorial three-way general linear model using JMP version 10 (SAS).