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. 2016 Mar 22;4:16001. doi: 10.1038/boneres.2016.1

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Copyright © 2016 Sichuan University

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Histomorphometric changes in bone formation. (a and b) Tetracycline double-labeled bone biopsies in a 57-year-old Caucasian female control (a) and a 58-year-old T2D Caucasian woman (b) bone formation is decreased in T2D with reduced mineralizing surface. The arrows highlight tetracycline uptake in the control subject and the absence of uptake in the diabetic subject. Adapted with permission from ref. 18.