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. 2015 Jul 28;10(1):45–54. doi: 10.1080/19336950.2015.1075677

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 2. — Snapshots of Nav1.5 structures aligned by their EFL domain. (A) Heterodimer of the structure of Nav1.5-CaM. (B) Nav1.5 bound to FHF and with CaM in extended conformation. (C) Nav1.5 bound to FHF with CaCaM as in 4JQ0. In (A–C), the structures are aligned by the EFL domain. (D) Close-up of helix αVI displaying the position of K1922, R1910 and K1899. (E) Similar to panel (B) but showing the same side chains as (D) to display the rotation of 90° around the helix αVI axis relative to the position of the other Nav1.5 molecule (light gray). (F) Displacement of helix aVI of the CTNav1.5-CaM-Ca-FHF (yellow) with respect to the CTNav1.5-CaM-FHF (green).