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. 2015 Jul 28;10(1):45–54. doi: 10.1080/19336950.2015.1075677

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 4. — CaM N-lobe conformations in Nav-CaM complexes. The structures of the CaM N-lobe in the different complexes are compared with the isolated CaM N-lobe with Mg²⁺ (green, 3UCW ^40,41) or CaM-Ca (magenta, 1CDM ⁴⁰). Helix αVI is shown in the structures in which there is an interaction between the CaM N-lobe and the helix. In the figure, CTNav1.5-CaM-FHF (navy blue, PDB ID 4DCK), CTNav1.5-CaM (marine, PDB ID 40VN), CTNav1.5-CaM-Ca-FHF (olive, PDB ID 4JQ0), CTNav1.2-CaM-Ca-FHF (teal, PDB ID 4JPZ), and CaM-Ca (magenta, PDB ID 1CDM) are shown. (A) Overlap of the CaM N-lobe as seen in CaM N-lobe with Mg²⁺ (PDB ID 3UCW) with CTNav1.5-CaM-FHF (navy, PDB ID 4DCK). (B) 90° rotation of A. (C) Overlap of the CaM N-lobe as seen in CaM-Ca (PDB ID 1CDM) with CTNav1.5-CaM.FHF (navy). (D) 90° rotation from C. (E, K) Alignment of the CTNav1.5-CaM N-lobe with CaM N-lobe-Mg (rmsd 0.4 Å). (H, N) Alignment of the CTNav1.5-CaM with CaM-Ca (rmsd 4.1 Å). (F, L) Alignment of the CTNav1.5-CaM-Ca-FHF N-lobe with CaM N-lobe-Mg (rmsd 3.4 Å). (I, O) Same as (F, L)with CaM-Ca (rmsd 1.4 Å). G, M. Alignment of the CTNav1.2-CaM-Ca-FHF N-lobe with CaM N-lobe-Mg (rmsd 3.2 Å). (J, P) Same as (G, M)with CaM-Ca (rmsd 1.45).