Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jul 28;10(1):45–54. doi: 10.1080/19336950.2015.1075677

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

PMC Copyright notice

Figure 8. — Location of mutations of Nav1.2 observed in autism and febrile seizures. (A) Surface representation of CTNav1.2 (top view, orange) interacting with CaM (teal) and FHF (lime green). Mutation of residue 1793 of the EFL domain is shown in gray. (B) CTNav1.2 mutations in gray (1902, 1918). (C) Close-up of residue R1902 close to the interface of CTNav1.2 with FHF. (D) Close-up of the position of residues Asp79 and Asp81 of CaM in the CTNav1.2-CaM-Ca-FHF (antiparallel; teal) vs CTNav1.5-CaM (parallel; marine).