Table 1.

Available CTNav structures. The table includes the residues of CTNav used in the study, the residues and lobe of CaM, whether or not Ca²⁺ was present in the experimental conditions, the orientation of CaM with respect to CTNav and the PDB ID of the structure. All the structures listes have the CaM C-lobe bound to the Nav IQ motif in a semi-open conformation

Identifier	Amino Acids	FGF	CaM*	Ca2+	N-lobe Config.	N-lobe Target	CaM Orient.	Method	PDB ID
IQNav1.5-CaM	1901–1927	no	1–148	apo	closed	none	NA§	NMR	2L5321
IQNav1.2-CaM	1901–1927	no	76–148#	apo	NA	NA	NA†	NMR	2KXW18
CTNav1.5-CaM-FGF	1773–1940	yes	1–148	apo	closed‡	none	NA§	X-ray	4DCK2
CTNav1.5-CaM-Ca-FGF	1773–1940	yes	1–148	Ca2+	open	post-IQ	anti-parallel	X-ray	4JQ03
CTNav1.2-CaM-Ca-FGF	1777–1937	yes	1–148	Ca2+	open‡	post-IQ	anti-parallel	X-ray	4JPZ3
CTNav1.5-CaM	1773–1929	no	1–148	apo	closed	EFL	parallel	X-ray	4OVN4

^*Hs: Homo sapiens, unless indicated.

^#Pt: Paramecium tetraurelia

^§CaM N-lobe is not bound, resulting in no determination of CaM lobes' orientation relative to Nav.

^†Only the CaM C-lobe was used, resulting in no determination of CaM lobes' orientation relative to Nav.

^‡The authors called the N-lobe in 4DCK semi-open, and closed in 4JPZ.³ See text and Fig 4 for discussion.