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. 2015 Sep 11;4(2):e1084084. doi: 10.1080/21623996.2015.1084084

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© 2015 Taylor & Francis Group, LLC

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Figure 2. — The interplay between canonical and non-canonical pools of STAT3 in maintenance of an undifferentiated (preadipocyte) phenotype. This graphical representation assumes that total STAT3 expression levels remain constant, irrespective of STAT3α or β. We speculate on the potential of the nuclear targeted STAT3-pY705 and mtSTAT3-pS727 maintaining a Warburg like effect with respect to downregulation of mitochondrial biogenesis and activity through STAT3-pY705 activity and stabilization of mitochondrial membrane potential and decreased ROS production through mtSTAT3-pS727. See text for further details.