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Proposed molecular mechanism of CaV1.2 modulation. CaM is bound to the CT at preIQ and IQ sites, the NT and CT of the channel are interacting, the channel is closed (left). The channel opens (middle), Ca2+ enters, binds to CaM, the NT and CT rearrange and the channel is inactivated (right). In the inactivated conformation, the possibility that a second CaM (light green) becomes bound to the NSCaTE is indicated.
