Table 3.
Hazard ratio of all-cause mortality according to different levels of systolic/diastolic blood pressure at baseline and during follow-up among patients with type 2 diabetes
| Systolic blood pressure/diastolic blood pressure (mmHg) | ||||||
|---|---|---|---|---|---|---|
|
| ||||||
| <110/65 | 110–119/65–69 | 120–129/70–79 | 130–139/80–89 | 140–159/90–99 | ≥160/100 | |
| Baseline | ||||||
| No. of Patients | 1,022 | 1,790 | 5,116 | 7,228 | 11,478 | 8,627 |
| No. of deaths | 234 | 302 | 576 | 747 | 1,216 | 1,124 |
| Person-years | 8,333 | 14,960 | 43,438 | 61,739 | 100,480 | 76,933 |
| Age, gender and race adjustment HR (95% CI) | 2.03 (1.75–2.35) | 1.50 (1.32–1.72) | 1.09 (0.98–1.22) | 1.00 | 0.96 (0.88–1.05) | 1.18 (1.08–1.30) |
| Multivariable adjustment HR (95% CI)a | 1.88 (1.57–2.26) | 1.29 (1.09–1.52) | 1.05 (0.92–1.20) | 1.00 | 0.93 (0.84–1.04) | 1.14 (1.02–1.27) |
| Multivariable adjustment HR (95% CI)b | 1.70 (1.42–2.04) | 1.26 (1.07–1.50) | 0.99 (0.86–1.12) | 1.00 | 0.92 (0.82–1.03) | 1.10 (0.98–1.23) |
| Follow-up | ||||||
| No. of Patients | 113 | 316 | 783 | 986 | 1,347 | 654 |
| No. of deaths | 185 | 996 | 5,455 | 9,076 | 11,634 | 3,716 |
| Person-years | 849 | 2,477 | 6,464 | 8,340 | 12,130 | 5,965 |
| Age, gender and race adjustment HR (95% CI) | 3.20 (2.63–3.89) | 2.34 (2.06–2.65) | 1.29 (1.18–1.42) | 1.00 | 0.92 (0.85–1.00) | 1.37 (1.24–1.51) |
| Multivariable adjustment HR (95% CI)a | 3.35 (2.56–4.39) | 1.97 (1.67–2.31) | 1.26 (1.12–1.41) | 1.00 | 0.93 (0.85–1.03) | 1.18 (1.04–1.35) |
| Multivariable adjustment HR (95% CI)b | 2.62 (2.00–3.44) | 1.77 (1.51–2.09) | 1.22 (1.09–1.36) | 1.00 | 0.90 (0.82–1.00) | 0.98 (0.86–1.12) |
Abbreviations: HR, hazard ratio; CI, confidence interval.
Adjusted for age, gender, race, type of insurance, income, and smoking.
Adjusted for age, gender, race, type of insurance, income, smoking, body mass index, low-density lipoprotein cholesterol, HbA1c, glomerular filtration rate, use of antihypertensive drugs, glucose-lowering agents, and cholesterol-lowering agents.