Table 2.
Analyses of Fibrosis Markers as Predictors of All Cause Mortality in HIV/HCV coinfected women
| Years before Final Observation# |
Fibrosis Marker |
% with severe fibrosis |
Univariate Analysis (OR, 95% CI) |
p value | Multivariate Analysis* (OR, 95% CI) |
p value |
|---|---|---|---|---|---|---|
| 0 | ELF | 42.9 | 12.23 (5.63–26.55) | <0.0001 | 15.01 (5.42– 41.61) | <0.0001 |
| 0 | FIB-4 | 31.8 | 8.89 (3.88– 20.37) | <0.0001 | 6.82 (2.58–18.03) | <0.0001 |
| 0 | APRI | 27.9 | 6.45 (2.81–14.79) | <0.0001 | 4.86 (1.77–13.34) | 0.0022 |
| 2 | ELF | 32.3 | 5.19 (3.04 –8.88) | <0.0001 | 4.66 (2.60–8.37) | <0.0001 |
| 2 | FIB-4 | 25.5 | 2.79 (1.61–4.83) | 0.0003 | 2.41 (1.30– 4.47) | 0.0051 |
| 2 | APRI | 17.0 | 2.09 (1.12–3.92) | 0.021 | 1.90 (0.95– 3.80) | 0.0712 |
| 4 | ELF | 22.1 | 3.10 (1.77– 5.44) | <0.0001 | 2.72 (1.46– 5.06) | 0.0016 |
| 4 | FIB-4 | 24.7 | 2.71 (1.58–4.66) | 0.0003 | 2.33 (1.26– 4.31) | 0.0068 |
| 4 | APRI | 13.7 | 2.34 (1.20–4.55) | 0.0126 | 1.92 (0.91– 4.09) | 0.0885 |
| 6 | ELF | 19.0 | 2.48 (1.37–4.49) | 0.0028 | 2.55 (1.36–4.76) | 0.0034 |
| 6 | FIB-4 | 19.3 | 1.99 (1.09–3.60) | 0.0239 | 1.62 (0.85– 3.10) | 0.1449 |
| 6 | APRI | 16.0 | 2.68 (1.42–5.04) | 0.0023 | 2.37 (1.22– 4.60) | 0.0107 |
Years before Final Observation: rows labeled as 0 refer to measurements within one year of the final observation; those labeled 2, 4 and 6 are 1–3 years, 3–5 years and 5–7 years respectively before final observations. At year of death 154 women contributed data; 282 women at 2 years; 299 women at 4 years; and 300 women at 6 years from death.
Multivariate analysis adjusting for log10 CD4 count (current and nadir CD4), and log10 HIV viral load, HAART use, and age as a continuous variable.
Results from logistic regression employed fibrosis markers that were dichotomized as severe or non-severe fibrosis using standard cutoff values of 10.43 for ELF, 3.25 for FIB-4 and 1.5 for APRI.