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. 2016 Mar 22;15:48. doi: 10.1186/s12933-016-0363-z

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© van Giessen et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Schematic representation of the model structure. NYHA New York Heart Association, HF heart failure. Within each NYHA state patients can either have detected or undetected heart failure. Following the screening strategy patients can be diagnosed with heart failure and transition from the undetected to the detected state may take place. Patients can transition from NYHA IV to NYHA I because of the (small) probability of transitioning to a better NYHA state in 1 month [22]. From the diabetes without HF and any of the NYHA states individuals can die from causes other than HF and transition to ‘Death other’