Table 3.

Power of association tests at markers linked to causal polymorphims according to LD extent in the association panel, heritability and effect of causal polymorphism (% of trait variance explained)

r 2 VS a	Mean power at the marker linked to causal polymorphismb
	h 2 = 0.5		h 2 = 0.7		h 2 = 0.9
	effect = 10 %	effect = 25 %	effect = 10 %	effect = 25 %	effect = 10 %	effect = 25 %
1	0.9	6.0	3.4	22.4	22.9	69.6
0.1	0.1	0.6	0.3	2.2	2.3	7.0
0.15	0.1	0.9	0.5	3.4	3.4	10.4
0.2	0.2	1.2	0.7	4.5	4.6	13.9
0.25	0.2	1.5	0.9	5.6	5.7	17.4
0.3	0.3	1.8	1.0	6.7	6.9	20.9
0.35	0.3	2.1	1.2	7.8	8.0	24.4
0.4	0.4	2.4	1.4	8.9	9.2	27.8
0.45	0.4	2.7	1.6	10.1	10.3	31.3

^aSquared correlation between the causal polymorphism and the linked marker, corrected by kinship and structure

^bMean power over the 314 SNPs with MAF > 5 % in the four genomic regions, assuming a family wise error rate of 5 % and using AIS kinship estimation, calculated as the power at the causal locus multiplied by the corrected LD between the causal locus and the marker