Figure 3.

The anaphase-promoting complex regulates neurogenesis, gliogenesis, and glial migration. (A) Cdh1–APC controls neurogenesis in the cerebral cortex and cerebellum and gliogenesis in Drosophila. Cdh1–APC promotes cortical neurogenesis via degradation of the cell cycle proteins Aurora A/B, Tpx2, and Cyclin B1 in neural precursor cells. In the cerebellum, Cdh1–APC may control neurogenesis via degradation of the protein kinase CK1δ. In Drosophila, Cdh1–APC limits gliogenesis via degradation of Loco, a regulator of G-protein signaling protein. (B) In Drosophila, Cdh1–APC controls peripheral glial migration along motor neuron axons. Cdh1–APC acts non-cell-autonomously in the establishment of a gradient of the immunoglobulin superfamily cell adhesion molecule Fas2 in motor neuron axons, leading to low levels of Fas2 proximally and high levels distally, facilitating glial migration along motor neuron axons.