Table 2.

Monoamine and metabolite levels in striatum and prefrontal cortex in saline- and MPTP-treated mice.

	Dorsolateral striatum		Prefrontal cortex
Measure	Saline	MPTP	Saline	MPTP
Dopamine	282.11 ± 17.67	128.47 ± 10.24****	4.12 ± 0.30	4.43 ± 0.61
DOPAC	16.83 ± 0.89	9.58 ± 0.70****	3.68 ± 0.99	2.36 ± 0.89
HVA	34.15 ± 2.23	28.23 ± 1.56*	3.96 ± 0.39	3.59 ± 0.37
3-MT	16.74 ± 1.18	16.01 ± 1.10	3.32 ± 1.08	2.09 ± 0.78
DOPAC/DA	0.06 ± 0.00	0.08 ± 0.00***	1.19 ± 0.56	0.20 ± 0.04
HVA/DA	0.12 ± 0.01	0.23 ± 0.01****	7.41 ± 2.66	13.95 ± 8.12
3-MT/DA	0.06 ± 0.00	0.12 ± 0.00****	0.71 ± 0.35	0.34 ± 0.14
Norepinephrine	0.14 ± 0.01	0.10 ± 0.01*	0.07 ± 0.01	0.08 ± 0.01
DA/NE	42.07 ± 5.29	13.52 ± 1.59****	1.60 ± 0.63	1.81 ± 0.84
5-HT	16.16 ± 0.68	18.15 ± 0.61*	16.00 ± 0.59	15.28 ± 0.76
5-HIAA	10.17 ± 0.39	11.46 ± 0.48*	5.37 ± 0.34	4.24 ± 0.32*
5-HIAA/5-HT	0.64 ± 0.03	0.63 ± 0.02	0.34 ± 0.02	0.28 ± 0.02*

All values are expressed in ng/mg tissue except those transformed to correct non-normal distributions as described in theMethods section. Because NE values were reciprocal-transformed, higher values indicate lower levels of NE. Abbreviations: DA, dopamine; NE, norepinephrine; DOPAC, 3,4-dihydroxyphenylacetic acid; HVA, homovanillic acid; 3-MT, 3-methoxytyramine; 5-HT, serotonin; 5-HIAA, 5-hydroxyindoleacetic acid.

^*p < .05.

^***p < .001.

^****p < .0001.