Fig. 3.
Effects of the CB1/2 agonist WIN 55,212-2 on choice behaviour in optimal and suboptimal groups of rats. The figure shows behaviour in the group of rats showing a preference for P3 and P4 (disadvantageous choices) under vehicle (suboptimal group) or in the group of rats showing a preference for P1 and P2 (advantageous choices) under vehicle (optimal group). Bars represent the average (±SEM) percentage of choice for the advantageous strategy (gray bars) and for the disadvantageous strategy (white bars) following the administration of the CB1/2 agonist WIN 55,212-2 in suboptimal rats (a) and optimal rats (b). *P<0.05, **P<0.01, versus vehicle, Fisher LSD post-hoc tests. The maximum number of pellets for each option is as follows: P1=295, P2=411, P3=135 and P4=99. The advantageous choice consisted of the percentage sum of responses on P1 and P2, whereas the percentage sum of responses on P3 and P4 options was considered the disadvantageous choice. LSD, least significant difference.